Deadpool, the alternate identity of Wade Winston Wilson, is a fictional antihero appearing in American comic books published by Marvel Comics. The character is featured in a 2016 film of the same name.
In honor of the Blu-ray release of Deadpool, Screen Junkies has released an "honest" trailer of the film which glorifies the sex and violence, comparing it to a "really expensive, longer episode of Family Guy." The trailer features footage from "The Cleveland-Loretta Quagmire" with Peter Griffin repeating "bam" in describing Quagmire's sex with Loretta Brown, although without audio. When Ryan Reynolds, appearing in character as Deadpool stops the action and wants to know what season of Family Guy are they referring to, he accepts the narrator's answer of the 4th season.
Peter sets up a cutaway gag in "Dog Bites Bear" when he declares that shaking hands with Boo Berry is the greatest thing to happen to him since he became the wise-cracking, Fourth wall-breaking superhero, Redstool. The ensuing action parodies that of the film.
Stewie notes that a kid with cancer at his preschool was visited by Ryan Reynolds in "Send in Stewie, Please", which he thinks had something to do with Deadpool.